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Rational Therapeutics
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Predictive Accuracy of Cell Death Assays

IN SELECT SOLID TUMOR TYPES

The following data compilation of 659 patients from 21 peer reviewed published articles in select solid tumor types establish the positive predictive accuracy of cell death assays at 77.0% and negative predictive accuracies of 87.9%. This breakdown reveals compelling evidence that assay directed therapies could improve response rates, time to progression and survival.

TYPE N TP TN FP FN Ref # Positive Predictive
Accuracy		 Negative Predictive Accuracy False Positive % False Negative %
Breast 47 31 13 3 0 1 91.2% 100.0% 6.4% 0.0%
Breast 29 17 5 4 2 2 81.0% 71.4% 13.8% 6.9%
Breast 17 9 6 1 1 3 90.0% 85.7% 5.9% 5.9%
Breast 85 56 10 17 0 4 76.7% 100.0% 20.0% 0.0%
Breast 4 2 2 0 0 5 100.0% 100.0% 0.0% 0.0%
Breast 12 6 4 0 2 20 100.0% 66.7% 0.0% 16.7%
Breast Total 194 121 40 25 5   82.9% 88.9% 12.9% 2.6%
                     
Colon 16 3 13 0 0 6 100.0% 100.0% 0.0% 0.0%
Colon 37 5 29 2 1 7 71.4% 96.7% 5.4% 2.7%
Colon 1 0 1 0 0 5 0.0% 100.0% 0.0% 0.0%
Colon Total 54 8 43 2 1   80.0% 97.7% 3.7% 1.9%
                     
NSCLC 8 5 2 1 0 8 83.3% 100.0% 12.5% 0.0%
NSCLC 6 0 6 0 0 9 0.0% 100.0% 0.0% 0.0%
NSCLC 8 0 8 0 0 5 0.0% 100.0% 0.0% 0.0%
NSCLC 25 7 11 5 2 10 58.3% 84.6% 20.0% 8.0%
NSCLC Total 47 12 27 6 2   66.7% 93.1% 12.8% 4.3%
                     
GYN 72 31 27 13 1 1 70.5% 96.4% 18.1% 1.4%
GYN 22 6 12 4 0 11 60.0% 100.0% 18.2% 0.0%
GYN 20 3 14 3 0 12 50.0% 100.0% 15.0% 0.0%
GYN 38 19 8 10 1 13 65.5% 88.9% 26.3% 2.6%
GYN 15 7 6 1 1 14 87.5% 85.7% 6.7% 6.7%
GYN 25 9 9 6 1 15 60.0% 90.0% 24.0% 4.0%
GYN 31 23 6 0 2 16 100.0% 75.0% 0.0% 6.5%
GYN 65 45 12 3 5 17 93.8% 70.6% 4.6% 7.7%
GYN 37 11 17 6 3 18 64.7% 85.0% 16.2% 8.1%
GYN 3 1 2 0 0 5 100.0% 100.0% 0.0% 0.0%
GYN 17 9 3 3 2 21 75.0% 60.0% 17.6% 11.8%
GYN Total 345 164 116 49 16   77.0%
87.9%		 14.2% 4.6%
                     
SCLC 1 1 0 0 0 19 100.0% 0.0% 0.0% 0.0%
SCLC 8 2 4 0 2 9 100.0% 66.7% 0.0% 25.0%
SCLC 10 0 7 3 0 5 0.0% 100.0% 30.0% 0.0%
SCLC Total 19 3 11 3 2   50.0% 84.6% 15.8% 10.5%
                     
Grand Total 659 308 237 85 26   78.4% 90.1% 12.9% 3.9%

Positive Predictive Accuracy: When assay predicted sensitivity, there was a response.
Negative Predictive Accuracy: When assay predicted resistance, there was no response.
PREDICTIVE ACCURACY OF CELL DEATH ASSAYS
IN SELECT SOLID TUMOR TYPES

REFERENCE LITERATURE

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