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Rational Therapeutics
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Abstracts

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• Functional Profiling of Human Tumors in Primary Culture: A Platform for Drug Discovery & Therapy Selection Robert A. Nagourney, Cheryl A. Kollin, Barbara Sommers, Yong-Zhuang Su, & Steven S. Evans. Malcolm Todd Cancer Institute, Long Beach, CA; Rational Therapeutics, Long Beach, CA.
  
• Clinical Response to EGFr-TKI’s characterized by drug-induced cell death in human NSCLC primary cultures. RA Nagourney, M. Paulsen, D. McConnell, R. Shuman. Todd Cancer Institute, Long Beach Memorial Medical Center, Long Beach, CA, Long Beach Memorial Medical Center, Long Beach, CA.
  
• Bortezomib combinations in ovarian cancer: Ex vivo analysis of activity and synergy in human tumor primary culture spheroids. Robert A. Nagourney, Cheryl A. Kollin, Barbara Sommers, et al. (2158) Amer Assoc of Canc Res 47, 2006.
  
• Casting-type calcification breast cancer: Assessment of response to cytotoxic insult in human tumor primary culture spheroids. RA Nagourney, B Sommers, S Evans, C Kollin, YZ Su, T Evans, J Islas, J Kakkis, L Tabar; Malcolm C. Todd Cancer Institute, Long Beach, CA; Central Hosp, Falun, Sweden.
  
• Assay directed chemotherapy in advanced solid tumors: A phase II trial. Jonathan Blitzer, Douglas McConnell, Carey Cullinane, Steven Grant, Kent Azaren, Thomas Asciuto, Imad Shbeeb, Jeffrey Islas, Barbara Sommers, Cheryl Jacobs, Sharon Davis, Karen Byczynski & Robert Nagourney. Malcolm C. Todd Cancer Institute, Long Beach, CA 90806
  
• The role of targeted therapies in ovarian cancer: Examination of drug activity in human primary culture spheroids. Steven Evans, Cheryl Brewer, Cheryl Kollin, Yong Zhuang Su & Robert Nagourney. University of Illinois, Peoria, Malcolm C. Todd Cancer Institute, University of California, Irvine & Rational Therapeutics, Inc. Long Beach, CA 90806. (5324) Amer Assoc of Canc Res 46, 2005
  
• The effects of EGFr modulation by Cetuximab & Gefitinib in human tumor primary culture microspheroids. Cheryl Kollin, Yong-Zhuang Su, Steven Evans, Robert Nagourney. Rational Therapeutics™ Inc., Long Beach, CA Amer Assoc of Canc Res 46, 2005 (abst)
  
• Geldenamycin & 17-allylamino-17-demethoxygeldenamycin alone and in combination with cytotoxic drugs in human tumor primary cultures. Robert Nagourney, Cheryl Kollin, Young Zhuang Su, Steven Evans: Malcolm C. Todd Cancer Institute, University of California, Irvine & Rational Therapeutics™, Inc. Long Beach, Ca 90806. (1713) Amer Assoc of Canc Res 46, 2005.
  
• Carboplatin & gemcitabine repeating doublet in recurrent breast cancer. RA Nagourney, J Link, B Sommers, W Lyons, J Blitzer, S Hager, M Flam; Malcolm C. Todd Cancer Institute, Long Beach, CA; Breastlink Medical Group, Long Beach, CA; Rational Therapeutics™ Inc., Long Beach, CA; Oncology Hematology Consultants, Long Beach, CA; California Cancer Center, Fresno, CA; Medical Oncology-Hematology Associates of Fresno, Fresno, CA.
  
• Gemcitabine/Antifol combinations in human tumor primary cultures: Potential role in gynecologic malignancies. Steven Evans, Cheryl Brewer, Yong-Zhuang Su, Christopher Yeung, Craig Chow, Dorothy Horlick, Cheryl Kollin, Robert Nagourney. Rational Therapeutics™, Long Beach, CA, University of Illinois, College of Medicine, Peoria, IL, Malcolm C. Todd
  
• Bortezomib (PS-341) alone and in combination with cytotoxic drugs: Ex vivo analysis in human tumor primary cultures. Robert A. Nagourney, Yong Zhuang Su, Dorothy Horlick, Craig Chow, Cheryl Kollin, Steven Evans. Malcolm C. Todd Cancer Institute, Long Beach, CA, Rational Therapeutics™, Long Beach, CA
  
• Effect pf gefitinib (Iressa, ZD 1839) in human tumor primary cultures: Possible insights into drug actions. Robert Nagourney, Craig Chow, Cheryl Kollin, Young Zhuang Su, Dorothy Horlick and Steven Evans. Rational Therapeutics™ Inc, Long Beach CA. Proc Amer Assoc Can Res 44, 870, 2003 (abstr),
  
• Capecitabine and vinorelbine in refractory ovarian malignancies. A pilot study. Cheryl A. Brewer, Rudy Segna, Barbara L. Sommers, Steve S. Evans, Christopher Yeung, and Robert A. Nagourney. Univ of Illinois College of Medicine at Peoria, Peoria, IL, Group for Women, NY (482) Amer Assoc of Canc Res 44, 110, 2003 (abst),
  
• Adrenocortical carcinoma therapy with cisplatin & gemcitabine: Laboratory and clinical correlates. Nagourney RA, Isaacs J., Bosserman L, BL Sommers, SS Evans; Rational Therapeutics™, Inc. Long Beach, CA; Hematology/Oncology Associates, Phoenix, AZ; Wilshire Oncology, Pomona, CA.. (1786) Proc Amer Soc Clin Oncol 22, 445, 2003 (abstr)
  
• A direct comparison of paclitaxel and Docetaxel activities in human tumors. Collin CA, Evans SS, Su, Y-Z Su, D Horlick, RA Nagourney; Rational Therapeutics Inc, Long Beach, CA. (655) Proc Amer Soc Clin Oncol 22, 163, 2003 (abstr)
  
• Arsenic Trioxide (AS2O3-TrisenoxTM) Single Agent and Combination Activity in Human Lung, Colon, Breast and Ovarian Tumor Primary (1o) Cultures Robert A. Nagourney, Yong Z. Su, Craig C. Chow, Cheryl A. Kollin, Dorothy V. Horlick and Steven S. Evans. Rational Therapeutics™, Inc, Long Beach, CA 90806 & University of California, Irvine. (2189) Proc Amer Soc Clin Oncol 21, 94b, 2002 (abstr)
  
• PC-SPES In Prostate Cancer: an Herbal Mixture Currently Containing Warfarin and Previously Diethylstilbestrol and Indomethacin. Sovak M; Seligson AL; Konas M; Hajduch M; Dolezal M; Machala M; Nagourney R. University of California, San Diego, Radiology Research, La Jolla, CA; Biophysica Foundation, La Jolla, CA; Interpharma Praha, Modrany, Czech Republic; Laboratory of Experimental Medicine, Department of Pediatrics, Palacky University in Olomouc, Czech Republic; Institute of Chemical Technology, Dept. Food Chemistry and Analysis, Prague, Czech Republic; Veterinary Research Institute, Brno, Czech Republic; University of California, Irvine, and Rational Therapeutics™, Long Beach, CA. Proc Amer Assoc Can Res 43:LB152, 2002 (abstr), San Francisco, CA April 6-10, 2002
  
• Iressa® (ZD1839) activity and synergy with cytotoxic drugs in human tumor primary cultures RA Nagourney, C Chow, YZ Su, C Kollin, D Horlick & SS Evans. Rational Therapeutics, Inc., Long Beach CA 90806 and University of California, Irvine. Proc Amer Assoc Can Res 43:787, 2002 (abstr), San Francisco, CA April 6-10, 2002.
  
• BEC, a mixture of solasodine glycosides reveals cytotoxic activity in human tumor primary culture specimens: Pre-clinical and early clinical observations YZ Su, DG Spall, MA Traill, C Kollin, C Chow, B. Sommers, S. Harper, D Horlick, SS Evans and RA Nagourney. Rational Therapeutics™, Inc. Long Beach, CA 90806 and OncoCare Cancer and Prostcare Clinic, Melbourne Australia. Proc Amer Assoc Can Res 43:214, 2002 (abstr), San Francisco, CA April 6-10, 2002.
  
• Ex-Vivo Assay (EVA-PCD™) Directed Cancer Chemotherapy: Feasibility and Utility in Clinical Practice R.A. Nagourney, K. Block, D. Spall, M. Flam, E. Rosenbaum, D. Lee, D. Berdeux, B. Sommers, S. Harper, S. Evans. Block Medical Center, Evanston, IL.; OncoCare Cancer and Prostcare Clinic, Melbourne, Australia, Hem/Onc. Associates of Fresno, CA. UCSF-Mt Zion Cancer Ctr, San Francisco, CA & Rational Therapeutics, Inc. Long Beach, CA 90806, USA. Proc Amer Soc Clin Oncol 20:103b, 2001 (abstr), San Francisco, CA May 12-15, 2001.
  
• Is Cisplatin & Gemcitabine Equivalent to Carboplatin & Gemcitabine? Yes and No S Evans, C Chow, YZ Su, R Hilton, D Horlick, C Harris and RA Nagourney. Rational Therapeutics™, Long Beach, CA 90806, USA. Proc Amer Soc Clin Oncol 20:99b, 2001 (abstr), San Francisco, CA May 12-15, 2001.
  
• Anvirzel, an Extract of Nerium Oleander Reveals Cytotoxic Activity in Human Tumors RA Nagourney, YZ Su, C Chow, R Hunt, S Evans. Rational Therapeutics™, Long Beach CA 90807. Proc Amer Assoc Can Res 42:634-635, 2001 (abstr) New Orleans, LA March 24-27, 2001
  
• Synergy between Topotecan and Other Cytotoxic Drugs in Human Tumors YZ Su, D Horlick, C Harris, SS Evans, B Sommers and RA Nagourney. Rational Therapeutics™, Inc., Long Beach, CA. Proc Amer Assoc Canc Res 42:253, 2001 (abstr), New Orleans, LA March 24-27, 2001
  
• Oxaliplatin vs Cisplatin Activity in Human Tumors S.S. Evans, C. Chow, Y.Z. Su, R. Hilton, R.A. Nagourney. Rational Therapeutics™, Inc., Univ of CA, Irvine, CA Proc Amer Soc Clin Oncol 19:228a, 2000 (abstr), New Orleans, LA, May 20-23, 2000.
  
• EVA-PCD™ (Assay-Directed Therapy of Advanced Ovarian Cancer P. Dottino, S.S. Evans, R. Segna, A.M. Beddoe, B. Sommers, R.A. Nagourney. Group for Women, New York, NY; Rational Therapeutics™ Inc., Long Beach CA, Univ of CA, Irvine, Irvine, CA Proc Amer Soc Clin Oncol 19:387a, 2000 (abstr), New Orleans, LA, May 20-23, 2000.
  
• Comparison of Cisplatin Combinations in Human Non-Small Cell Lung Cancer (NSCLC). R.A. Nagourney, C. Chow, Y. Su, S. Evans; Rational Therapeutics™ Inc., Long Beach, CA; Univ of CA, Irvine, CA, Proc Amer Soc Clin Oncol 19:544a, 2000 (abstr), New Orleans, LA, May 20-23, 2000.
  
• BCLxL Expression in Human Tumors: Correlation with Ex-Vivo Drug Resistance Profiles in Primary Cultures Robert A. Nagourney, Yong Z Su, Steven S Evans, Stanislaw Krajewski, Maria Krajewska, and John C Reed. Burnham Institute, La Jolla, CA and Rational Therapeutics™, Inc., Proc Amer Assoc Canc Res 41:404, 2000 (abstr), San Francisco, CA April 1-5, 2000.
  
• Herceptin Enhancement of Cytotoxic Drug Activity in Human Tumor Primary Cultures Nagourney RA, Evans SS, Chow C, Su YZ. Rational Therapeutics™, Inc. Long Beach, CA & University of California, Irvine. 22nd Annual San Antonio Breast Cancer Symposium, 1999; 57:116,.San Antonio, TX, December 8-11, 1999.
  
• Phase II Trial of Gemcitabine & Cisplatin in Heavily Pretreated, Relapsed Breast Cancer Nagourney RA, Blitzer J, Forstoff C, Link J. Rational Therapeutics™, Long Beach, CA 90807, Memorial Breast Cancer, Long Beach, CA & University of California, Irvine. Proc. Amer. Soc. Clin. Oncol. 1999;39-428, Atlanta, GA, May 14-18, 1999.
  
• Activity Profile of Trimetrexate (TMTX) & 5-Fluorouracil (5FU) in Human Tumors. SS Evans, YZ Su, J Danskin, C Chow, D Horlick, C Harris & RA Nagourney. Rational Therapeutics™, Long Beach, CA 90807 & University of California, Irvine. Proc. Amer. Soc. Clin. Oncol 1999; 740, Atlanta, GA, May 14-18, 1999.
  
• Cisplatin (Cddp) & Fludarabine (FAMP) in Relapsed High (H) & Intermediate (I)-Grade Non-Hodgkins lymphomas (NHL): Laboratory & Clinical Observations. YZ Su, SS Evans, JB Blitzer, V Priego and RA Nagourney. Rational Therapeutics™ Inc, Long Beach, CA 90807 and University of California, Irvine. Proc Amer Soc Clin Oncol 1999;39-142, Atlanta, GA, May 14-18, 1999.
  
• Gemcitabine & Cisplatin "Repeating Doublet" Therapy in Heavily Pre-Treated, Relapsed Breast Cancer. Nagourney RA. Lilly Oncology Global Medical Conference, Indianapolis, IN May 12, 1999.
  
• Arsenic Trioxide (AS203) Activity Spectrum In Human Tumors. Nagourney RA, Danskin JW, Chow C, Su YZ, Evans SS. Rational Therapeutics, Inc., Long Beach, CA 90807 & University of California, Irvine 92668. Proc Amer. Assoc. for Cancer Research 1999;39-2626, Philadelphia, PA, April 10-13, 1999.
  
• Gemcitabine Synergy With Nitrogen Mustard In Human Tumors. Evans SS, Chow C, Danskin JW, Su YZ, Nagourney RA. Rational Therapeutics, Long Beach, CA 90807 & University of California, Irvine 92668. Proc. Amer. Assoc. for Cancer Research 1999;39-3891. Philadelphia, PA, April 10-13, 1999.
  
• Gemcitabine (dfdc) Combination Therapy: Current Observations & Future Directions Nagourney, RA, Dottino P, DiSaia P, Link J, Su YZ, Evans SS.. Rational Therapeutics™, Long Beach, CA, University of California, Irvine CA & Mt. Sinai Medical Center, New York, NY Proc. US Gemzar (Gemcitabine HCI) Investigators Meeting, New Orleans, LA, March 11-13-1999.